GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4356975 | 1 | rs4356975 | chr4:69972463 | UGT2B11 | chr4:70066053-70080449:- | -0.19 | -3.65 | 0.000294 | Obesity-related traits |
| THCA | cis | rs6825911 | 1 | rs4358460 | chr4:111382685 | ENPEP | chr4:111397229-111484491:+ | 0.17 | 4.09 | 4.99E-5 | Blood pressure |
| THCA | cis | rs4915077 | 1 | rs4359051 | chr1:108373414 | VAV3 | chr1:108113782-108507545:- | 0.57 | 8.13 | 3.62E-15 | Hypothyroidism |
| THCA | cis | rs2262909 | 1 | rs436039 | chr19:22214873 | ZNF257 | chr19:22235266-22273901:+ | 0.33 | 6.68 | 6.87E-11 | Chagas cardiomyopathy in Tripanosoma cruzi seropositivity |
| THCA | cis | rs13315871 | 1 | rs4362735 | chr3:58429893 | PXK | chr3:58318617-58410878:+ | 0.32 | 5.87 | 8.34E-9 | Cholesterol, total |
| THCA | cis | rs4363385 | 1 | rs4363385 | chr1:152989321 | SPRR3 | chr1:152974223-152976332:+ | -0.15 | -3.36 | 0.000833 | Inflammatory skin disease |
| THCA | cis | rs997295 | 1 | rs4363822 | chr15:67992583 | C15orf61 | chr15:67813522-67819638:+ | 0.12 | 3.36 | 0.00084 | Motion sickness |
| THCA | cis | rs997295 | 1 | rs4363822 | chr15:67992583 | IQCH | chr15:67547188-67794139:+ | 0.17 | 5.27 | 2.09E-7 | Motion sickness |
| THCA | cis | rs997295 | 1 | rs4363822 | chr15:67992583 | MAP2K5 | chr15:67835021-68099451:+ | 0.15 | 3.64 | 0.000308 | Motion sickness |
| THCA | cis | rs300774 | 1 | rs436446 | chr2:106409 | SH3YL1 | chr2:218138-264810:- | -0.27 | -4.27 | 2.36E-5 | Suicide attempts in bipolar disorder |
| THCA | cis | rs6494537 | 1 | rs4366668 | chr15:65903398 | DPP8 | chr15:65737999-65810035:- | -0.1 | -4.19 | 3.35E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs4366668 | chr15:65903398 | SLC24A1 | chr15:65903704-65953256:+ | -0.16 | -3.88 | 0.000117 | Mean corpuscular hemoglobin |
| THCA | cis | rs6017291 | 1 | rs4366964 | chr20:42895906 | C20orf111 | chr20:42825137-42839431:- | -0.24 | -3.48 | 0.000546 | Cognitive performance |
| THCA | cis | rs13315871 | 1 | rs4367085 | chr3:58389235 | PXK | chr3:58318617-58410878:+ | 0.34 | 5.99 | 4.19E-9 | Cholesterol, total |
| THCA | cis | rs10935120 | 1 | rs4367113 | chr3:134287975 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.93 | 5.06E-33 | Height |